Article: Altered intrinsic properties of neuronal subtypes in malformed epileptogenic cortex.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) George AL; Jacobs KM Brain Res., 2011
Table 1Intrinsic properties of layer V interneurons and pyramidal cells.
Values are means±SEM. n, number of cells; FS, fast-spiking cells; LTS, low-threshold spiking cells; Pyr, pyramidal cells; ** indicates significant difference between control and PMG for an indivdual neuronal subtype, Student's t-test, p<0.05; § indicates significant difference between FS and LTS within a particular subject group, Student's t-test, p<0.05.
Electrophysiological parameter | FS | LTS | Pyr |
Control (n=34) | Control (n=33) | Control (n=29) | |
PMG (n=30) | PMG (n=23) | PMG (n=22) | |
1st spike duration, ms | 0.77±0.04§ | 1.08±0.05 | 1.86±0.08 |
0.81±0.06§ | 1.03±0.05 | 2.03±0.12 | |
2nd spike duration, ms | 0.79±0.04§ | 1.23±0.06 | 2.35±0.13 |
0.84±0.07§ | 1.17±0.06 | 2.84±0.22** | |
Duration increase, % | 2.8±0.6§ | 13.4±1.4 | 25.8±4.4 |
2.7±1.0§ | 12.6±1.7 | 39.6±6.9 | |
1st spike AHP, mV | −11.8±0.6§ | −8.6±0.6 | −3.9±0.7 |
−11.5±0.6§ | −7.2±0.9 | −3.3±0.6 | |
2nd spike AHP, mV | −14.9±0.6§ | −11.2±0.6 | −14.0±0.8 |
−14.6±0.6§ | −10.0±0.9 | −14.8±0.8 | |
Early adaptation ratio | 0.08±0.02 | 0.11±0.02 | 0.22±0.02 |
0.09±0.02 | 0.07±0.01 | 0.16±0.03 | |
Late adaptation ratio | 0.86±0.02§ | 0.55±0.03 | 0.77±0.02 |
0.83±0.01§ | 0.55±0.04 | 0.76±0.01 | |
Accommodative hump, mV | 4.8±0.6§ | 1.5±0.2 | 3.4±1.1 |
4.3±0.6§ | 2.2±0.6 | 3.1±1.3 | |
Minimal frequency, Hz | 32.4±3.6§ | 9.2±0.6 | 6.3±0.3 |
25.5±3.3§ | 11.6±2.3 | 6.7±0.5 | |
Time for min freq., ms | 188±21 | 201±14 | 175±9 |
171±17 | 170±16 | 176±12 |